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09 Oct 07
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Science - Not So Sloppy

Recent Wall Street Journal coverage1 has revived interest in Dr. John Ioannidis’ 2005 PLoS article, "Why Most Published Research Findings Are False."2 Somehow, I missed it the first time around, but this time the paper got me to thinking. In short, I don’t buy his argument; I think the whole foundation is wrong.

Background

First, for those who haven’t read his paper, or don’t follow the math, let me outline what he’s saying.

He’s talking about a certain kind of experiment, one that’s much more prevalent in medicine than it is in, say, physics. In medicine, it commonly appears in the form of clinical trials.3

tagged as: research, mathematics, medical research, probability, and significance, 10 nerd-its

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